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SARS-CoV-2 is activated for fusion by a broad range of proteases, finds study – News-Medical.Net

A team of researchers from the University of Virginia, USA, used single-virus fusion experiments with exogenously controlled proteases to investigate the mechanism…



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It is well known that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds with the angiotensin-converting enzyme 2 (ACE2) receptor on the host cell surface. This process facilitates host-virus membrane fusion, with cell entry achieved by host proteases.
The particular host protease utilized varies amongst betacoronaviruses, though SARS-CoV-2 appears to use cathepsins primarily, usually found in the late endosome, suggesting that SARS-CoV-2 enters the cell by the endocytotic pathway….

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